Teviral 1 | Chronic Hepatitis B Virus (HBV) Infection
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Teviral 1 | 1 Strip

Generic: Entecavir

Type: Tablet

Pack Size: 10 Pcs

Entecavir, a guanosine nucleoside analogue, competitively inhibits HBV DNA polymerase (reverse transcriptase, rt) by interfering with:

  • Base priming
  • Reverse transcription of the negative strand from pregenomic mRNA
  • Positive-strand synthesis of HBV DNA

After phosphorylation by kinases, entecavir is incorporated into viral DNA, thereby inhibiting HBV polymerase and blocking viral replication.

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✅ Description:

Teviral is indicated for the treatment of chronic hepatitis B virus (HBV) infection in adults and pediatric patients 2 years of age and older with:

Evidence of active viral replication, and

Either persistent elevation in serum aminotransferases (ALT/AST) or histologically active liver disease.

Pediatric: Safety and efficacy established for ≥2 years; not recommended <2 years.

Geriatric: Limited data in patients ≥65 years; caution advised, monitor renal function.

Renal Impairment (dose adjustment):

  1. CrCl ≥50 mL/min: 0.5 mg every 24 hr
  2. CrCl 30–49 mL/min: 0.5 mg every 48 hr
  3. CrCl 10–29 mL/min: 0.5 mg every 72 hr
  4. CrCl <10 mL/min, Hemodialysis or CAPD: 0.5 mg every 7 days

Safety Advices


Alcohol
UNSAFE

The interaction of alcohol with Entecavir is unknown. Please consult a doctor before consuming alcohol while using Entecavir.


Pregnancy
CAUTION

Entecavir is a category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks


Breastfeeding
CAUTION

It is unknown whether Entecavir is excreted in human milk. Therefore, please consult a doctor if you are breastfeeding. Entecavir is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.


Driving
CAUTION

Entecavir may cause dizziness, drowsiness, or tiredness in some people. Therefore, avoid driving or operating heavy machinery if you feel dizzy, drowsy, or tired after taking Entecavir.


Kidney
CONSULT YOUR DOCTOR

Take Entecavir with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Please consult a doctor


Liver
CONSULT YOUR DOCTOR

Take Entecavir with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Please consult a doctor.

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✔️ Overdose Effects | Teviral 1

Limited clinical experience.

Healthy volunteers tolerated doses up to 20 mg/day for 14 days and single doses up to 40 mg without unexpected adverse events.

In case of overdose: monitor patient and provide standard supportive care.

✔️ Side Effects | Teviral 1

Common:

Headache

Fatigue

Dizziness

Nausea

Rare but Serious:

Lactic acidosis

Severe hepatomegaly with steatosis

Acute flare of hepatitis after treatment discontinuation

✔️ Dosage & Administration | Teviral 1
  • Treatment-naïve adults & adolescents ≥16 years: 0.5 mg once daily
  • Lamivudine-refractory or Lamivudine/Telbivudine resistance: 1 mg once daily
  • Decompensated liver disease (adults): 1 mg once daily

Administration: Should be taken on an empty stomach (≥2 hours after or before a meal).

Missed Dose:

  • If close to next dose → skip missed dose.
  • Do not double the dose to make up for a missed one.
✔️ Interaction

No significant interaction with Lamivudine or Adefovir dipivoxil.

Caution required with drugs eliminated via renal pathways or those affecting renal function.

Monitor for adverse events when co-administered with nephrotoxic agents.

✔️ Contraindications

Known hypersensitivity to Entecavir or any excipient of the formulation.

✔️ Precautions & Warnings
  • Lactic acidosis & hepatomegaly with steatosis: Reported with nucleoside analogues; can be fatal.
  • Hepatitis exacerbation on discontinuation: Monitor closely after stopping therapy.
  • Renal impairment: Dose adjustment required for CrCl <50 mL/min.
  • HIV co-infection: Should not be used as monotherapy due to the risk of HIV resistance.
✔️ Pregnancy & Lactation

Pregnancy: Insufficient data; use only if potential benefit outweighs risk. The transmission risk of HBV from mother to infant is not fully established.

Lactation: Unknown if excreted in human milk → breastfeeding not recommended during treatment.

✔️ Storage:

Store in a cool, dry place below 30°C.

Protect from light.

Keep out of reach of children.

Frequently Asked Questions (FAQ)

Hepatitis B is a serious liver infection caused by the hepatitis B virus (HBV). It is highly contagious and spreads through: Intimate contact with an infected person Direct contact with infected blood Sharing razors, needles, or personal items contaminated with infected fluids From mother to baby during childbirth 👉 The virus can survive up to 7 days outside the body. Chronic infection develops slowly, often without symptoms until complications such as liver cirrhosis, liver failure, or liver cancer appear. Prevention: Hepatitis B can be prevented by vaccination.

No. Stopping Entecavir suddenly can worsen the infection or cause relapse. 👉 Take it for as long as prescribed and consult your doctor before making any changes.

Yes. Entecavir may interact with celecoxib and other medicines that affect the kidneys, increasing the risk of side effects. 👉 Always inform your doctor about all medicines you are taking.

Entecavir is not recommended as monotherapy for patients with HIV. It can cause HIV resistance if taken without proper HIV treatment. 👉 Patients should be tested for HIV before starting Entecavir.

Common: Headache, fatigue, nausea, dizziness Rare but serious: Lactic acidosis (excess lactic acid in blood) and liver enlargement with fat buildup ⚠️ If you develop stomach pain, vomiting, yellowing of the eyes/skin, or unexplained tiredness, contact your doctor immediately.

No. Entecavir does not cure hepatitis B, but it helps control the infection, reduce liver damage, and improve liver function.

Yes. HBV is highly contagious and can spread through blood, body fluids, or from mother to child at birth. 👉 Avoid sharing razors, toothbrushes, or needles with infected individuals.

Entecavir works by blocking the action of HBV DNA polymerase, an enzyme essential for the virus to multiply. This prevents the virus from replicating and helps lower viral load in the body.

Entecavir is an antiviral medicine used to treat chronic hepatitis B infection. It reduces the amount of virus in the body and helps protect the liver from damage.
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⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

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